Protein Details: Glutamate receptor ionotropic;NMDA 3A
Protein ID
ICDB_Pro_1314
Protein Name
Glutamate receptor ionotropic;NMDA 3A
Gene Name
GRIN3A; KIAA1973
Organism
Homo sapiens (Human)
Length
1115 amino acids
AlphaFoldDB
AF-Q8TCU5-F1-model_v4.pdb
Function
NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance;low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. During the development of neural circuits;plays a role in the synaptic refinement period;restricting spine maturation and growth. By competing with GIT1 interaction with ARHGEF7/beta-PIX;may reduce GIT1/ARHGEF7-regulated local activation of RAC1;hence affecting signaling and limiting the maturation and growth of inactive synapses. May also play a role in PPP2CB-NMDAR mediated signaling mechanism.
Sequence
Ligand Binding
Binding Site
Disease
Epilepsy and West Syndrome
Location
DOI ID
10.1006/geno.2001.6666; 10.1016/s0304-3940(01)02524-1; 10.1093/dnares/8.6.319; 10.1038/nature02465; 10.1101/gr.2596504; 10.1196/annals.1300.049; 10.1523/jneurosci.21-20-07985.2001; 10.1038/tp.2011.52
RefSeq
NP_597702.2